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Mutation of the additional neighboring residues identified two that had significant effects: Ile239 from the B′-C» loop and Arg288 from the F′-G′ loop. Residues in this region that connects the BN and BC domains may form interactions that are important for maintaining the correct orientation of the domains and thus may have indirect effects on ligand binding. Between the sequences of the CRH domains of G-CSF receptor and growth hormone receptor we found a 34% sequence similarity and 13% sequence identity, which is in a range where homology modeling is difficult, but still feasible. Drag the item whose appearance you want to change into the Target Weapon* window.

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